Asociación de atrofia medial del lóbulo temporal en TC e hipocaptación temporoparietal mediante SPECT / Association between medial temporal lobe atrophy on ct and parietotemporal uptake decrease on SPECT to the study of cognitive impairment and depressive symptoms

La tomografía computarizada (TC) y la resonancia magnética (RM) cerebrales aportan a la evaluación diagnóstica del paciente con depresión y deterioro cognoscitiva significativo una excelente información anatómica, mientras la tomografía computarizada de emisión de fotón único (SPECT cerebral), permite obtener una información funcional a través de la medición del flujo sanguíneo cerebral regional (FSCr). Objetivo: Evaluar la validez de la combinación de atrofia del lóbulo medial temporal e hipocaptación temporoparietal al diagnóstico de demencia degenerativa primaria, así como su capacidad para discriminar entre demencia degenerativa primaria y depresión. Material: 23 pacientes, 9 hombres (39,1 por ciento) y 14 mujeres (60,9 por ciento), edad media de 61 años, con el diagnóstico de depresión y deterioro cognoscitivo significativo sin cumplir criterios de demencia, según códigos diagnósticos GMS-HAS y DSM-IV. 10 individuos sanos, de similares características sociodemograficas y sin historia anterior de trastorno psiquiátrico, neurológico ni abuso de drogas. Métodos: se ha realizado sistemáticamente tomografía axial computarizada (TC) y por emisión de fotón único (SPECT) cerebrales en sujetos mayores de 65 años con un MEC <24 y menores de 65 años con un MEC > 27. Resultados: se han establecido 6 patrones de perfusión cerebral para el grupo de pacientes El más frecuentemente observado fue el patrón C (39,13 por ciento), hipoperfusión temporal y/o parietal bilateral. Conclusiones:

[Molecular forms of PSA and differentiating between benign hypertrophy,carcinoma, and disseminated prostatic carcinoma. Correlation between two determination technics]. / Formas moleculares de PSA en la discriminación entre hipertrofia benigna, carcinoma y carcinoma diseminado de próstata. Correlación entre dos diferentes técnicas de determinación.

OBJECTIVE: To determine the correlation between two methods of measurement of total PSA (PSA-T) and free PSA (PSA-F) and the utility of the PSA-F/PSA-T ratio in patients with PSA-T between 4 and 10 ng/ml suspected as having prostate cancer. METHODS: Determinations of both PSA-T and PSA-F were performed using two different techniques in 91 patients suspected as having prostate cancer. Diagnosis was made on the findings of biopsy and the complementary tests. RESULTS: The following correlation was found for the two techniques: R = 0.99 and p < 0.05 for PSA-T, and R = 0.85 and p < 0.05 for PSA-F. For PSA-T values of 4-10 ng/ml and PSA-F greater than 25%, we found two patients with prostate cancer. For a PSA-F/PSA-T ratio less than 9%, all cases had prostate cancer. Three cases with bone metastasis had PSA-T values less than 10 ng/ml. CONCLUSIONS: A PSA-F/PSA-T ratio greater than 25% does not exclude malignancy in patients with a total PSA of 4-10 ng/ml; values less than 9% correspond to prostate cancer. Bone metastasis was found with both methods in patients with total PSA values less than 10 ng/ml.

[Reliability of the evaluation of regional cerebral blood flow using SPECT in chronic schizophrenia and bipolar disorder]. / Fiabilidad de la evaluación del flujo sanguíneo cerebral regional FSCR mediante SPECT en esquizofrenia crónica y trastorno bipolar.

OBJECTS: Demonstrate the reliability of cerebral SPECT using 99 mTc-HMPAO. METHODS & MATERIALS: Evaluation of cerebral blood flow using SPECT in 24 patients with schizophrenia, 24 patients with bipolar disorder and 20 controls. In the study we have reliability between observers and intraobserver. In both cases kappa statistic has been applied for measuring reliability. RESULTS: reliability between observers represents a kappa coefficient of 0.71. Intraobserver reliability, with a medium grade concordance slightly superior, shows a medium kappa coefficient of 0.74. CONCLUSIONS: Visual evaluation of SPECT images using 99mTc--HMPAO is a trustworthy technique to document the different patterns of regional cerebral blood flow. Reliability is determinate by the improvement, during visual analysis of reliability between observers (kappa: 0.71) and intraobservers (kappa: 0.74).

[Gerstmann-Straussler syndrome clinical and neuromorphofunctional diagnosis: a case report]. / Síndrome de Gerstmann-Straussler: Diagnóstico clínico y neuromorfofuncional. A propósito de un caso.

UNLABELLED: The Syndrome of Gerstmann-Straussler is a constellation of typical symptoms that affects the parietotemporal crossroad and also involves the contiguous parts of the occipital lobe of the dominant hemisphere. Is a family ailment that starts with an espinocerebellar ataxy followed by dementia. Diagnosis options such as EEG, TC, RM and brain SPECT-99mTc-HMPAO have been carried out in an adult with Gerstmann Syndrome. RESULTS: The brain SPECT disclosed a disminution of the flow at the parietotemporooccipital areas of both hemispheres. The results revealed a clinical and a neuromorphofunctional correlation. CONCLUSION: Brain SPECT is a complementary test to the structural neuroradiological examinations, such as TC and RM, that occasionally is useful not only to clarify but also to widen the information that these offer.